This study sought to investigate the interactions of University, Industry and Government in science and technology, scientific production in the country during 1985-2015.In this study, the Triple Helix model is used to determine the relationship between university, industry and government, scientific production in the field of science and technology. Accordingly all articles during this period with at least one address of Iran, including 267097 articles in the field of science and technology were extracted and studied through Web of Science.Iranian scientific productions in the field of science and technology had an upward trend during the mentioned time. The mutual interactions between university-government, had the highest value and the lowest value accounted industry-government interactions. T value (three dimension relationship) of university, industry and government has been decreasing in the last three decades and has trended toward zero during recent years.The strong association between university, industry and government, a flourishing industry and technology in the country. Unfortunately, in terms of scientific production, that is an indicator of relationship between these three organs, a good situation cannot be seen in the country. Undoubtedly, investments and implementation of sustainable policies for strengthening of the relations between the three organs, and efforts to eliminate barriers to cooperation of these pillars will follow positive results and a dramatic increase in Triple Helix indicators in scientific production in the country.